{"_buckets": {"deposit": "6e98c77a-669d-4593-b89e-83ed8fa839bb"}, "_deposit": {"created_by": 31, "id": "243", "owners": [31], "pid": {"revision_id": 0, "type": "depid", "value": "243"}, "status": "published"}, "_oai": {"id": "oai:kwmed.repo.nii.ac.jp:00000243", "sets": ["357"]}, "author_link": ["126719", "126720"], "item_1694495855422": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_type": "VoR"}]}, "item_3_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1988", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "81", "bibliographicPageStart": "75", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "Kawasaki medical journal", "bibliographic_titleLang": "en"}]}]}, "item_3_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "2", "subitem_description_type": "Other"}]}, "item_3_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00010217699", "subitem_description_type": "Other"}]}, "item_3_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original Article", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_3_identifier_14": {"attribute_name": "URL", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1988en/14(2)75-81.1988.pdf"}]}, "item_3_relation_20": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.11482/KMJ-E14(2)75 ", "subitem_relation_type_select": "DOI"}}]}, "item_3_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00710169", "subitem_source_identifier_type": "NCID"}, {"subitem_source_identifier": "AA12029005", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-0234", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2434-3404", "subitem_source_identifier_type": "EISSN"}]}, "item_3_text_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_text_value": "The Effects of Long-Term Treatment with Lithium on Adenylate Cyclase Coupled with Catecholamine Receptors"}]}, "item_3_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Psychiatry, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Psychiatry, Kawasaki Medical School"}]}, "item_3_textarea_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_textarea_language": "en", "subitem_textarea_value": "Increment of cyclic AMP in tissue slices in response to noradrenaline and dopamine stimulation was studied in all part of the rat brain. Chronic lithium administration significantly inhibited the sensitivity of noradrenaline-sensitive adenylate cyclase in the frontal cortex, whereas the sensitivity of dopamine-sensitive adenylate cyclase was significantly inhibited in bulbus olfactorius and hippocampus. A possible relationship between the antidepressant action of lithium and its significant inhibition of the sensitivity of noradrenaline-sensitive adenylate cyclase was therefore suggested. The anti-manic effect, on the other hand, may be related to the inhibitory action on the sensitivity of dopamine-sensitive adenylate cyclase. 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