| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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タイトル |
Serum Concentration of Flomoxef in Administration of One Hour Infusion Every Eight Hours a Day |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
MATSUSHIMA, Toshiharu
NAKAMURA, Junichi
KOBASHI, Yoshihiro
KAWANISHI, Masayoshi
TANO, Yoshihiko
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| 著者所属(英) |
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en |
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Department of Medicine 2, Kawasaki Hospital, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Medicine 2, Kawasaki Hospital, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
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Department of Medicine 2, Kawasaki Hospital, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Medicine 2, Kawasaki Hospital, Kawasaki Medical School |
| 著者所属(英) |
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|
en |
|
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Department of Medicine 2, Kawasaki Hospital, Kawasaki Medical School |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Flomoxef(FMOX) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Blood concentration |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Respiratory infection |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Multi-divided administration |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
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|
en |
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Flomoxef (FMOX) is a new, parenteral oxacephem antibiotic with strong, broad-spectrum antimicrobial activity. To compensate for short half time of this drug, multi-divided administration of the drug was attempted, and the concentrations of FMOX in the blood were determined. The treatment by dripping intravenous infusion of FMOX thrice daily or one hour infusion every eight hours were carried out in six patients with an indwelling intravenous catheter. Four patients had pneumonia and the other two suffered from respiratory infections with lung cancer. With the patient's permission, six blood samples were drawn from each patient just before and after infusions, and the concentration of FMOX was determined by bioassay. The mean serum concentration in the six patients ranged between three troughs just before infusion and three peaks just after infusion, being 1.40 μg/ml, 2.59 μg/ml and 1.84 μg/ml, and 47.32 μg/ml, 52.17 μg/ml and 50 μg/ml, respectively. These concentrations, even troughs, were higher than the MIC90 of almost all bacteria considered to be sensitive to FMOX. In fact, five out of six patients showed a good response to this treatment. No side effects were observed, except mild and transient elevation of transaminase in one case. In conclusion, we recommend the administration of FMOX thrice daily for patients with severe pulmonary infections, especially from the standpoint of its blood concentration. |
| 書誌情報 |
en : Kawasaki medical journal
巻 15,
号 2,
p. 59-63,
発行日 1989
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| URL |
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|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1989en/15(2)59-63.1989.pdf |
|
識別子タイプ |
URI |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ-E15(2)59 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
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出版タイプ |
VoR |
KJ00010214099.pdf (431.6 kB)
