| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
Clinical Study on Concentrations of Lomefloxacin in Pleural Fluid |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
MATSUSHIMA, Toshiharu
NAKAMURA, Junichi
KAWANISHI, Masayoshi
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| 著者所属(英) |
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|
en |
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Department of Medicine, Kawasaki Hospital, Kawasaki Medical School |
| 著者所属(英) |
|
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en |
|
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Department of Medicine, Kawasaki Hospital, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Medicine, Kawasaki Hospital, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Lomefloxacin |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
New quinolone |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Pleural fluid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Drug concentration |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
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en |
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A single dose of lomefloxacin, a new oral antibacterial agent with excellent antibacterial potency and spectrum and safety profile, was administered at 200 mg, the recommended dose, to 6 patients with accumulated pleural fluid in order to determine drug concentrations in the pleural fluid over time after treatment. Lomefloxacin appeared in the pleural fluid 1 hr after oral treatment in some cases. The mean concentration increased gradually from 0.49 μg/ml 2 hrs after treatment to 0.81, 1.00 and 1.16 μg/ml, respectively, 3, 4 and 6 hrs after treatment. A concentration of 0.45 μg/ml was still present 24 hrs after treatment. The AUC determined up to 24 hrs after treatment was 18.51 μg hr/ml. Concentrations reached in the pleural fluid 2 hrs after treatment, in particular those reached 3 hrs after treatment, were higher than MICs of lomefloxacin for most bacteria against which the drug has been found to be effective, and concentrations remained above MICs over a long period of time. In addition, concentrations in the pleural fluid obtained in different patients showed very little variability, although the drug was orally administered. This finding suggests that the drug's absorption from the intestine and the passage through the pleura are very stable. Therefore, lomefloxacin seems to be a drug of choice for use in studies on passage of drues through various barriers. |
| 書誌情報 |
en : Kawasaki medical journal
巻 15,
号 3･4,
p. 97-103,
発行日 1989
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| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1989en/15(3.4)97-103.1989.pdf |
|
識別子タイプ |
URI |
| DOI |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.11482/KMJ-E15(3.4)97 |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010214819.pdf (654.4 kB)
