| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
Kinetic Studies of Lipid Exchanges in Red Cell Membranes in Hereditary High Red Cell Membrane Phosphatidylcholine Hemolytic Anemia : Reference to the Abnormal Accumulation of Phosphatidylcholine in These Membranes |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
OTSUKA, Akiyo
SUGIHARA, Takashi
YAWATA, Yoshihito
|
| 著者所属(英) |
|
|
|
en |
|
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Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
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Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
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|
en |
|
|
Department of Medicine, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hereditary high red cell membrane phoshatidylcholine hemolytic anemia(HPCHA) |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Phosphatidylcholine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lyso-phosphatidylcholine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Obstructive jaundice |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
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|
en |
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The pathogenesis of the accumulation of phosphatidylcholine (PC) in red cell membranes of the patients with hereditary high red cell membrane phosphatidylcholine hemolytic anemia (HPCHA) was studied utilizing 14C-PC and 14C-lyso-PC. The uptake of 14C-PC was not significantly different in the red cell membranes with HPCHA from that in normal controls and obstructive jaundice in whom red cell membrane PC and free cholesterol (FC) were elevated to the same extent as that in HPCHA. The efflux of 14C-PC with HPCHA was slightly decreased, in comparison with that in the normal controls and obstructive jaundice. The most striking data were obtained in the uptake of 14C-lyso-PC by the red cells of the HPCHA patients, showing more than two fold increase when compared with that in the normal control. The conversion of 14C-lyso-PC to 14C-PC was increased in comparison with that in the normal controls and obstructive jaundice. In summary, the exact cause of the abnormal accumulation of PC through increased uptake of lyso-PC, followed by the increased conversion of lyso-PC to PC is unknown. In obstructive jaundice of an acquired origin, some compensatory mechanism may exist to prevent the further accumulation of lipids in the red cell membranes. |
| 書誌情報 |
en : Kawasaki medical journal
巻 15,
号 3･4,
p. 113-122,
発行日 1989
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| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1989en/15(3.4)113-122.1989.pdf |
|
識別子タイプ |
URI |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E15(3.4)113 |
| ISSN |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010214879.pdf (885.3 kB)
