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Functional assessment of retinal pigment epithelium cell transplants with various degrees of pigmentation for age-related macular degeneration
https://kwmed.repo.nii.ac.jp/records/2923
https://kwmed.repo.nii.ac.jp/records/2923721e3aec-5cc8-439e-921b-07a74af9a2ef
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (1.2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2022-10-21 | |||||||||
| タイトル | ||||||||||
| タイトル | Functional assessment of retinal pigment epithelium cell transplants with various degrees of pigmentation for age-related macular degeneration | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
SETOGUCHI, Yoshinao
× SETOGUCHI, Yoshinao
× KIRYU Junichi
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| 著者所属(英) | ||||||||||
| 言語 | en | |||||||||
| 値 | Department of Ophthalmology 1, Kawasaki Medical School | |||||||||
| 著者所属(英) | ||||||||||
| 言語 | en | |||||||||
| 値 | Department of Ophthalmology 1, Kawasaki Medical School | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | AMD | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | RPE | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Transplant | |||||||||
| 抄録(英) | ||||||||||
| 言語 | en | |||||||||
| 値 | Age-related macular degeneration (AMD) is the major cause of blindness and reduced vision among adults in Japan, for which only symptomatic therapy using an anti-vascular endothelial growth factor (anti-VEGF) drug is currently available. Recently, transplantation of retinal pigment epithelium (RPE) cells derived from human embryonic or pluripotent stem cells has been extensively applied in clinical practice as a radical therapy for patients with AMD; however, its therapeutic effect remains limited. RPE cells have melanin pigment granules that increase over time; moreover, the degree of pigmentation (dPG) increases with the number of pigment granules. The expression levels of RPE-specific genes and the secretion of cytokines reportedly increase as dPG increases. In this study, we performed functional characterization of human RPE (h-RPE) cells with low and high dPG to determine which might be suitable for transplantation to patients with AMD. Specifically, we isolated h-RPE cells with low and high dPG based on evaluation of lightness parameters, then characterized these cells separately. Our results showed that RPE cells with low dPG exhibited elevated phagocytosis and cell adhesiveness, as well as reduced VEGF secretion, compared with RPE cells with high dPG. Because these traits are considered preferable for transplantation to patients with AMD, RPE cells with low dPG may be more suitable for transplantation. Cellular senescence (indicated by levels of senescence-related proteins) was more advanced in RPE cells with high dPG, suggesting that cellular senescence is an important factor that contributes to the suitability of RPE cells for transplantation to patients with AMD. | |||||||||
| 書誌情報 |
en : Kawasaki medical journal 巻 46, p. 49-58, 発行日 2020 |
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| 出版者 | ||||||||||
| 出版者 | Kawasaki Medical Society | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 03850234 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 24343404 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12685295 | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12029005 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E202046049 | |||||||||
| 記事種別(英) | ||||||||||
| 内容記述 | Regular Article | |||||||||
| 医中誌ID | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | ICHUSHI | |||||||||
| 関連識別子 | 2022017985 | |||||||||
| 関連サイト | ||||||||||
| 識別子タイプ | URI | |||||||||
| 関連識別子 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2020en/KMJ-E202046049.pdf | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
