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The Mode of the Staircase Phenomenon in Relation to Ryanodine Sensitivity in Rat Papillary Muscle, Bullfrog Atrium and Frog Ventricle
https://kwmed.repo.nii.ac.jp/records/293
https://kwmed.repo.nii.ac.jp/records/293fc247acd-01b5-430f-ae42-3897e9057a65
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00010211319.pdf (1.1 MB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-01-23 | |||||||||
| タイトル | ||||||||||
| タイトル | The Mode of the Staircase Phenomenon in Relation to Ryanodine Sensitivity in Rat Papillary Muscle, Bullfrog Atrium and Frog Ventricle | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
OKITA, Yukio
× OKITA, Yukio
× MATSUMURA, Moto
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| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Physiology, Kawasaki Medical School | ||||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Physiology, Kawasaki Medical School | ||||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Heart muscle contraction | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Staircase phenomenon | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Ryanodine | |||||||||
| 記事種別(英) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Original Article | |||||||||
| 言語 | en | |||||||||
| 抄録(英) | ||||||||||
| en | ||||||||||
| Frog ventricular muscle, when repetitively stimulated at an interval of 1 sec, showed a gradual increase in contraction strength; i.e., the positive staircase phenomenon. The tension of rat papillary muscle, on the other hand, was maximum in the first contraction, after which it decreased gradually during repetitive stimulation; the negative staircase phenomenon. The tension of bullfrog atrial muscle was large in the first contraction, but decreased in the next 15 to 20 contractions and then increased in the following ones. The tension was small if the stimulation interval was prolonged in frog ventricular muscle (positive relationship between contraction strength and stimulation interval). This relationship was reversed in rat papillary muscle. The optimum Ca2+ concentrations for maximum tension development at a stimulation interval of 5 sec were 7.2-9.0 mM in frog muscles and 3.6 mM in rat muscles. Ryanodine inhibited the contraction in rat papillary muscle at lower concentration than those in bullfrog atrial muscle, and it had much less effect on frog ventricular muscle. These results indicate that tissue having high sensitivity to ryanodine exhibits the negative staircase phenomenon, a negative relationship between interval and strength, and low dependency on external Ca2+ concentration. | ||||||||||
| 書誌情報 |
en : Kawasaki medical journal 巻 16, 号 1, p. 23-32, 発行日 1990 |
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| URL | ||||||||||
| 識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1990en/16(1)23-32.1990.pdf | |||||||||
| 識別子タイプ | URI | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E16(1)23 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0385-0234 | |||||||||
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| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2434-3404 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00710169 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12029005 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
