| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-10-21 |
| タイトル |
|
|
タイトル |
Reactive oxygen metabolites as a biomarker of congenital heart disease in children |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
OHNO, Naoki
KONDO, Eisuke
AKAIKE, Hiroto
MIYATA, Ippei
OGITA, Satoko
OISHI, Tomohiro
OUCHI, Kazunobu
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Reactive oxygen metabolites |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Biological antioxidant potential |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Biomarkers |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Congenital heart disease |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Brain natriuretic peptide (BNP), as a hematological biomarker, has been widely used in congenital heart disease (CHD). However, its sensitivity and specificity vary depending on age and pathological condition. In the present study, we assessed whether reactive oxygen metabolites (ROMs) and biological antioxidant potential (BAP), as oxidative stress indicators, could be new biomarkers in CHD.
Forty-two patients diagnosed with CHD were enrolled in this study. The levels of ROMs, BAP, BNP, cardiac muscle creatinine kinase, and heart-type fatty acid-binding protein were measured using the findings of echocardiography. The ROM and BNP levels were significantly higher than the standard reference levels. The estimated Qp/Qs correlated mildly with BNP and ROM levels. The medication caused a significant decrease in BNP and ROM levels. The optimal decision, Qp/Qs greater than 1.5, estimated from receiver operator characteristic (ROC) curves was 371 U.CARR (58% sensitivity, 90% specificity) for ROMs, and that for BNP was 28.4 pg/ml (97% sensitivity 45% specificity). Direct comparison of ROMs and BNP did not show significantly different area under the curve values.
ROM levels can be a new biomarker for oxidative stress evaluation in children with CHD at almost the same sensitivity as the previous biomarkers, and an effective indicator when combined with other biomarkers and indicators. |
| 書誌情報 |
en : Kawasaki medical journal
巻 46,
p. 125-133,
発行日 2020
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03850234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202046125 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
| 医中誌ID |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
ICHUSHI |
|
|
関連識別子 |
2022017993 |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2020en/KMJ-E202046125.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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