| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-10-21 |
| タイトル |
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タイトル |
Predictors for the outcomes of patients with estrogen receptor-positive, HER2-negative advanced breast cancer treated using palbociclib plus endocrine therapy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
YAMAMOTO, Yutaka
OGATA, Ryohei
KANOMATA, Naoki
KISHINO, Emi
MORIYA, Takuya
KUREBAYASH, Junichi
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| 著者所属(英) |
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en |
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Department of Breast and Thyroid Surgery, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Breast and Thyroid Surgery, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Pathology, St. Luke’s International Hospital |
| 著者所属(英) |
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en |
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Department of Breast and Thyroid Surgery, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Breast and Thyroid Surgery, Kawasaki Medical School |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
Palbociclib |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Predictors |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Response |
| キーワード |
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Progression-free survival |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Overall survival |
| 抄録(英) |
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|
en |
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A cyclin-dependent kinase (CDK) 4/6 inhibitor, palbociclib (PAL), combined with endocrine therapy is frequently used for the treatment of patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor (HER) 2-negative advanced breast cancer. However, as predictors for the outcomes remain unclear, we retrospectively investigated them.
A total of 36 patients with ER-positive, HER2-negative advanced breast cancer were treated using PAL plus endocrine therapy at our hospital. Treatment outcomes, objective response rates (ORR), progression-free survival (PFS) and post-treatment overall survival (OS) were analyzed. As possible predictive biomarkers, retinoblastoma protein (Rb), phosphorylated Rb (pRb) and different CDKs were immunohistochemically investigated using primary tumor tissues. Non-visceral metastasis, use of fulvestrant (FUL) and the 1st- or 2nd-line treatment were significant predictors for a better ORR (P = 0.0080, P = 0.0080 and P = 0.0080, respectively). No objective response (OR) was observed in patients with progesterone receptor (PR)-negative, CDK6-positive or cytosolic cyclin E1-positive tumors. Non-visceral metastasis and use of FUL were significant predictors for a better PFS (P = 0.0030 and P = 0.0443, respectively). The Cox proportional hazards model revealed that visceral metastasis (hazard ratio [HR], 4.9; P = 0.0019) and PR-negativity (HR, 3.2; P = 0.0411) were independent predictors for a poorer PFS. Nonvisceral metastasis, pRb-negativity and CDK6-negativity were significant predictors for a better OS (P = 0.0281, P = 0.0014 and P = 0.0396, respectively). The Cox proportional hazards model revealed that visceral metastasis (HR, 7.2; P = 0.0131) and pRb-positivity (HR, 18.5; P = 0.0060) were independent predictors for a poorer OS.
In conclusion, PR-negativity and pRb-positivity in primary tumors may be independent predictors for PFS and OS, respectively. CDK6-positivity and cytosolic cyclin E1-positivity may be predictors for a poorer OS and ORR, respectively. Further investigation is needed to confirm these factors. |
| 書誌情報 |
en : Kawasaki medical journal
巻 46,
p. 135-143,
発行日 2020
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| 出版者 |
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出版者 |
Kawasaki Medical Society |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
03850234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
24343404 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA12685295 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ-E202046135 |
| 記事種別(英) |
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内容記述 |
Regular Article |
| 医中誌ID |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
ICHUSHI |
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関連識別子 |
2022017994 |
| 関連サイト |
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識別子タイプ |
URI |
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関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2020en/KMJ-E202046135.pdf |
| 著者版フラグ |
|
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (2.1 MB)
