| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-04-01 |
| タイトル |
|
|
タイトル |
Dipeptidyl peptidase-4 inhibitor linagliptin reduces urinary albumin excretion through the protection of glomerular endothelial function |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
KONDO, Megumi
KIDOKORO, Kengo
UCHIDA, Atsushi
KADOYA, Hiroyuki
UMENO, Reina
TOKUYAMA, Atsuyuki
WADA, Yoshihisa
NAGASU, Hajime
KANDA, Eiichiro
SASAKI, Tamaki
KASHIHARA, Naoki
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology, Tsukuba Medical Center Hospital |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Medical Science, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Departments of Nephrology and Hypertension, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Diabetic kidney disease |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glucagon-like peptide-1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Endothelial dysfunction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oxidative stress |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glomerular permeability |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Glycocalyx |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Background: In most developed countries, diabetic kidney disease is the most common cause of chronic kidney disease, leading to end-stage renal disease, and it is also associated with cardiovascular diseases, including heart failure, and a higher risk of other microvascular complications. A recent clinical trial indicated that the dipeptidyl peptidase-4 inhibitor linagliptin prevents the occurrence and progression of albuminuria in patients with type 2 diabetes. Thus, this study aimed to elucidate the molecular mechanism underlying the inhibitory effect of linagliptin on albuminuria in diabetic kidney disease. Methods: Control C57BL/6 mice and diabetic Ins2+/Akita mice were orally administered linagliptin (5 mg/kg/ day) every day for 8 weeks. Results: Compared to control mice, Ins2+/Akita mice had markedly elevated blood glucose and HbA1c levels, but there were no significant changes after linagliptin treatment. Furthermore, albuminuria and urinary 8-OHdG levels were significantly increased and glomerular mesangial area was significantly expanded in Ins2+/Akita mice compared to those in control mice; these changes were ameliorated by linagliptin treatment, which also improved the degradation of glomerular endothelial glycocalyx and enhancement of glomerular permeability of macromolecules. The activity of AMP-activated protein kinase and the expression of guanosine 5'-triphosphate cyclohydrolase I in human glomerular endothelial cells were significantly lower in high glucose conditions and were improved by linagliptin or GLP-1 administration. Discussion: These results together suggest that linagliptin reduced albuminuria in a blood glucose-independent manner via the reduction of oxidative stress and maintenance of the glycocalyx in endothelial cells. Thus, earlier treatment with linagliptin may slow the progression of diabetic kidney disease. |
| 書誌情報 |
en : Kawasaki medical journal
巻 47,
p. 131-141,
発行日 2021
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| 出版者 |
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|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03850234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202147131 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147131.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (4.5 MB)
