| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-04-01 |
| タイトル |
|
|
タイトル |
Methamphetamine concentrations in gastric contents and blood after parenteral and oral administration in rats |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
YOSHITOME, Kei
MORIYA, Fumio
MIURA, Masanobu
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Legal Medicine, Kawasaki Medical School・Department of Legal Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Nursing, Faculty of Nursing, Kawasaki University of Medical Welfare・Department of Legal Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Legal Medicine, Kawasaki Medical School・Department of Legal Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Methamphetamine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Administration route |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Parenteral administration |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Drug concentration in gastric content |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
It is important, yet difficult, to distinguish the route of administration, parenteral or oral, of methamphetamine on postmortem examination. It might be possible to determine the route of administration by comparing the methamphetamine concentrations in the blood and stomach. However, the changes in methamphetamine concentrations in gastric contents and blood after oral and parenteral administration are unknown. Therefore, the time course of the ratio of methamphetamine concentration in gastric contents and blood (the GB ratio) was investigated using rats to which methamphetamine was administered subcutaneously (subcutaneous group) or orally (oral group). The maximum GB ratio and the maximum mean GB ratio in the subcutaneous group were 54.2 and 31.5, respectively. On the other hand, the GB ratio was 6.38-5,749 in the oral group. Therefore, it is difficult to distinguish the route of methamphetamine administration using the GB ratio alone. However, if the time from administration of methamphetamine to death can be proven, and it is less than 3 h, the route of administration could be clearly identified by measuring methamphetamine concentrations in the blood and gastric contents. Moreover, it might be suggested that the GB ratio would not exceed a certain value (54.2 was observed) after parenteral methamphetamine administration in rats. |
| 書誌情報 |
en : Kawasaki medical journal
巻 47,
p. 159-166,
発行日 2021
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03850234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202147159 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147159.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (974.1 kB)
