| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-03-10 |
| タイトル |
|
|
タイトル |
Changes in serum antibody titers after vaccination for COVID-19 and evaluation of post-vaccination health conditions |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
OHIRA, Shin
NAKANO, Takashi
UESUGI, Satoe
KOUGUCHI, Yutaka
TAMURA, Masayo
HIRAMATSU, Takako
ATARASHI, Mihoe
NAKATSUKA, Tota
HIRATA, Keita
TANAKA, Takaaki
KIMURA, Tomohiko
KANDA, Eiichiro
TOHYAMA, Kaoru
OTOMO, Takanobu
NAGAI, Atsushi \n
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Urology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Clinical Laboratory, Kawasaki Medical School Hospital |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Clinical Laboratory, Kawasaki Medical School Hospital |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Clinical Laboratory, Kawasaki Medical School General Medical Center |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Nursing, Kawasaki Medical School Hospital |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Nursing, Kawasaki Medical School General Medical Center |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Urology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Urology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pediatrics, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Medical Science, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Laboratory Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Molecular and Genetic Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Director of Kawasaki Medical School Hospital |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
COVID-19 vaccine |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Introduction of vaccination |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Serum antibody titer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Health condition survey |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Introduction: The coronavirus disease 2019 (COVID-19) vaccine has preventive effects and high immunogenicity, but the outcomes of vaccination have not been widely reported. The goal of this study was to examine serum antibody titers before and after vaccination and to evaluate post-vaccination health conditions.
Methods: The subjects were 2,304 medical workers (mean age 41 years) at Kawasaki Gakuen who agreed to participate in the study and underwent COVID-19 vaccination, beginning in March 2021. Serum IgG antibody titers for SARS-CoV-2 spike protein were measured before the first vaccination and 4 weeks after the second vaccination. Health conditions were observed for 4 weeks after the second vaccination.
Results: The rates of seroconversion, seroprotection, and change in geometric mean antibody titer at 4 weeks after the second vaccination were 99.9%, 99.9%, and 2,685.5 (95% CI 587.8-5,319.2), respectively, suggesting high immunogenicity. After the first vaccination, pain, enlargement, and reddening occurred at the local injection site, and systemic side effects included fatigue, headache, physical pain, chill, nausea, and fever. After the second vaccination, the incidence of pain decreased, but those of other events increased. There were no serious side effects requiring hospitalization. In logistic regression analysis, sex, age, fever,chill, and lymph node enlargement after the second vaccination were associated with a change in antibody titer.
Conclusions: Serum antibody titers suggested high immunogenicity of the COVID-19 vaccine and a health condition survey confirmed the safety of the vaccine. Systemic side effects may serve as an index of immunization (acquisition of antibody) by the vaccine. |
| 書誌情報 |
en : Kawasaki medical journal
巻 48,
p. 73-85,
発行日 2022
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| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202248073 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 関連サイト |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022en/KMJ-E202248073.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (1.4 MB)
