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Role of the expression of collagen prolyl-4-hydroxylase α subunits 1 and 2 in the development and prognosis of breast cancer
https://kwmed.repo.nii.ac.jp/records/3058
https://kwmed.repo.nii.ac.jp/records/30587ec9130d-e3be-4f16-b4d7-976cfa97829d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (14.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2023-03-10 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Role of the expression of collagen prolyl-4-hydroxylase α subunits 1 and 2 in the development and prognosis of breast cancer | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
MIKAMI, Yuka
× MIKAMI, Yuka
× NISHIMURA, Hirotake
× ISODA, Ryutaro
× MIKAMI, Tsuyoshi
× YAMAMOTO, Yutaka
× KUREBAYASHI, Junichi
× MORIYA, Takuya
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| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Pathology | |||||||||||||||||||
| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Pathology | |||||||||||||||||||
| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Pathology・Department of General Surgery | |||||||||||||||||||
| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Breast and Thyroid Surgery, Kawasaki Medical School | |||||||||||||||||||
| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Breast and Thyroid Surgery, Kawasaki Medical School | |||||||||||||||||||
| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Breast and Thyroid Surgery, Kawasaki Medical School・Department of Medical Engineering, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare | |||||||||||||||||||
| 著者所属(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Department of Pathology | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Breast cancer | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Prolyl-4-hydroxylase (P4H) | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Triple-negative breast cancer (TNBC) | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Hypoxia inducible factor (HIF) | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Epithelial-mesenchymal transition (EMT) | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | Immunohistochemistry | |||||||||||||||||||
| 抄録(英) | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 値 | Background: The expression of prolyl-4-hydroxylase (P4H), an enzyme involved in collagen biosynthesis, is significantly upregulated during breast cancer development and progression. However, the molecular mechanisms by which P4H expression in cancer cells induces progression have not been elucidated. Thus, we aimed to determine the significance of the expression of isoforms 1 and 2 of P4H in breast cancer. Methods: We performed immunohistochemical analysis for P4HA1 and P4HA2 on the tumor samples obtained from 182 patients with breast cancer and examined the correlation between clinicopathological factors and markers related to epithelial-mesenchymal transition and ischemia. Protein expression levels were investigated using western blotting. In addition, breast cancer cell cultures were used to characterize the expression. Results: Expression of both P4HA1 and P4HA2 was upregulated in cancer cells compared with that in normal mammary glands; the high-P4H expression group tended to have a poorer prognosis than the low-P4H expression group. In particular, P4HA2 was strongly associated with tumor grade; P4HA2 expression showed a weak negative correlation with HIF-2α expression. In cultured breast cancer cells, the immunohistological expression of P4H and HIF increased to various degrees under hypoxia, while P4H protein levels increased in a time-dependent manner. Conclusion: P4HA2 can be used as a marker of breast cancer grade and a prognostic factor. Differential expression of P4HA1 and P4HA2 was observed in an ischemic environment, suggesting that each may be affected by the type of collagen involved. |
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| 書誌情報 |
en : Kawasaki medical journal 巻 48, p. 87-104, 発行日 2022 |
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| 出版者 | Kawasaki Medical Society | |||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||
| 収録物識別子 | 24343404 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA12029005 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E202248087 | |||||||||||||||||||
| 記事種別(英) | ||||||||||||||||||||
| 内容記述 | Regular Article | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
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| 識別子タイプ | URI | |||||||||||||||||||
| 関連識別子 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022en/KMJ-E202248087.pdf | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
