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Sorafenib-induced apoptosis in colonic neuroendocrine carcinoma cells
https://kwmed.repo.nii.ac.jp/records/3065
https://kwmed.repo.nii.ac.jp/records/30656e387548-863c-435d-8f1c-cf829fcc2564
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PDF (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2023-03-10 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Sorafenib-induced apoptosis in colonic neuroendocrine carcinoma cells | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
YAMAMURA, Masahiro
× YAMAMURA, Masahiro
× YAMAUCHI, Akira
× TONE, Shigenobu
× YAMAGUCHI, Yoshiyuki \n\n
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| 著者所属(英) | ||||||||||||||
| 言語 | en | |||||||||||||
| 値 | Department of Clinical Oncology | |||||||||||||
| 著者所属(英) | ||||||||||||||
| 言語 | en | |||||||||||||
| 値 | Department of Biochemistry, Kawasaki Medical School | |||||||||||||
| 著者所属(英) | ||||||||||||||
| 言語 | en | |||||||||||||
| 値 | Laboratory of Molecular Developmental Biology, Graduate School of Science and Engineering, Tokyo Denki University | |||||||||||||
| 著者所属(英) | ||||||||||||||
| 言語 | en | |||||||||||||
| 値 | Department of Clinical Oncology | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Neuroendocrine carcinoma | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | COLO320 | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Angiogenesis inhibitor | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Sunitinib | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Sorafenib | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | Apoptosis | |||||||||||||
| 抄録(英) | ||||||||||||||
| 言語 | en | |||||||||||||
| 値 | Background: Neuroendocrine carcinoma (NEC) is a rare disease, and therapy for this malignant tumor is controversial. Conventionally, platinum doublet chemotherapy has been used for advanced gastroentero-pancreatic (GEP) neuroendocrine carcinoma (GEP- NEC), but the efficacy of molecular-targeted drugs for GEP-NEC is unknown. In this study, we investigated the antitumor effect of molecular-targeted drugs on colorectal neuroendocrine carcinoma cells. Materials and methods: A colonic neuroendocrine carcinoma cell line COLO320 was treated with molecular-targeted drugs, and cell growth suppression and apoptosis induction were evaluated. Results: The cytostatic effects of molecular-targeted drugs against COLO320 were higher in the order of sorafenib, sunitinib, rapamycin, and imatinib. Flow cytometry analysis showed that sorafenib induced G1 cell cycle arrest and a high rate of apoptosis. Sunitinib showed condensation and fragmentation of nuclear chromatin, but also necrosis with cell swelling. In contrast, sorafenib strongly induced apoptosis via condensation and fragmentation of nuclear chromatin. Sorafenib-induced apoptosis was due to caspase-3 activation, and this apoptosis was inhibited with a caspase inhibitor. Conclusion: Sorafenib induces apoptosis in COLO320 cells and is a potential therapeutic agent for colonic neuroendocrine carcinomas. |
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| 書誌情報 |
en : Kawasaki medical journal 巻 48, p. 175-182, 発行日 2022 |
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| 出版者 | ||||||||||||||
| 出版者 | Kawasaki Medical Society | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 24343404 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA12029005 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E202248175 | |||||||||||||
| 記事種別(英) | ||||||||||||||
| 内容記述 | Regular Article | |||||||||||||
| 言語 | en | |||||||||||||
| 関連サイト | ||||||||||||||
| 識別子タイプ | URI | |||||||||||||
| 関連識別子 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022en/KMJ-E202248175.pdf | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
