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Very Long Chain Fatty Acid Contents in the Sera of Patients with Adrenoleukodystrophy and Adrenomyeloneuropathy Measured by Selected-Ion-Monitoring Gas Chromatography/Mass Spectrometry
https://kwmed.repo.nii.ac.jp/records/323
https://kwmed.repo.nii.ac.jp/records/32306253494-b170-45ce-9e99-23b2a1161053
名前 / ファイル | ライセンス | アクション |
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2017-01-23 | |||||||
タイトル | ||||||||
タイトル | Very Long Chain Fatty Acid Contents in the Sera of Patients with Adrenoleukodystrophy and Adrenomyeloneuropathy Measured by Selected-Ion-Monitoring Gas Chromatography/Mass Spectrometry | |||||||
言語 | en | |||||||
言語 | ||||||||
言語 | eng | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
KAWAI, Kingo
× KAWAI, Kingo
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著者所属(英) | ||||||||
en | ||||||||
Department of Neurology, Kawasaki Medical School | ||||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Saturated very long chain fatty acids | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Adrenoleukodystrophy | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Adrenomyeloneuropathy | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Selected-ion-monitoring gas chromatography/mass spectrometry | |||||||
記事種別(英) | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | Original Article | |||||||
言語 | en | |||||||
抄録(英) | ||||||||
en | ||||||||
Saturated very long chain fatty acid (VLCFAs, C22:0 - C28 :0) contents in the sera of 9 adrenoleukodystrophy (ALD) patients, 4 adrenomyeloneuropathy (AMN) patients, and 11 age-matched normal controls were determined by gas chromatography (GC), GC/mass spectrometry (MS) and selected-ion-monitoring (SIM)-GC/MS. The following results were obtained. The C22:0 contents of the ALD and AMN groups were not significantly different from those of the control group. However, the C24: 0 contents of the ALD and AMN groups were respectively, 1.9 and 1.5 times higher than control, and the C26:0 contents of these groups measured by SIM-GC/MS were 7.7 and 7.8 times higher than the control. These contents were about half of those measured by GC alone. The C28 :0 content of human sera could be measured for the first time in this study using SIM-GC/MS. The order of the increasing rate of the individual VLCFAs of ALD and AMN as compared that with the control was as follows, C26 : 0 > C28 : 0 > C24 : 0. | ||||||||
書誌情報 |
en : Kawasaki medical journal 巻 17, 号 1-4, p. 29-36, 発行日 1991 |
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URL | ||||||||
識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1991en/17(1.2.3.4)29-36.1991.pdf | |||||||
識別子タイプ | URI | |||||||
DOI | ||||||||
識別子タイプ | DOI | |||||||
関連識別子 | https://doi.org/10.11482/KMJ-E17(1.2.3.4)29-36.1991 | |||||||
ISSN | ||||||||
収録物識別子タイプ | PISSN | |||||||
収録物識別子 | 0385-0234 | |||||||
ISSN | ||||||||
収録物識別子タイプ | EISSN | |||||||
収録物識別子 | 2434-3404 | |||||||
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収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA00710169 | |||||||
雑誌書誌ID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA12029005 | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR |