| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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タイトル |
Reduced Expression of the Survivin Gene in PBMC from Silicosis Patients |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
GUO, Zhong-Qiu
OTSUKI, Takemi
SHIMIZU, Toshiyuki
TACHIYAMA, Shiho
SAKAGUCHI, Haruko
TOMOKUNI, Akiko
HYODOH, Fuminori
KUSAKA, Masayasu
UEKI, Ayako
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| 著者所属(英) |
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en |
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Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
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en |
|
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Department of Applied Medical Engineering, Kawasaki College of Allied Health Professions |
| 著者所属(英) |
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en |
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Department of Applied Medical Engineering, Kawasaki College of Allied Health Professions |
| 著者所属(英) |
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en |
|
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Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
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en |
|
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Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
|
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en |
|
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Department of Hygiene, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of Internal Medicine, Kusaka Hospital |
| 著者所属(英) |
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en |
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Department of Hygiene, Kawasaki Medical School |
| キーワード |
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言語 |
en |
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主題Scheme |
Other |
|
主題 |
silicosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
survivin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
apoptosis |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immunological disorders |
| 抄録(英) |
|
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|
en |
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To explore the mechanism involved in immunological disorders associated with silicosis, the expression of IAP family genes in peripheral blood mononuclear cells from silicosis patients was examined. Relative gene expression was assayed using the multiplex RT-PCR for the XIAP and survivin genes. The correlation between those expression levels and various clinical parameters was then analyzed. The relative expression level of the survivin gene was reduced in silicosis patients as compared with that of healthy volunteers. The expression level of survivin positively correlated with PCO_2 values. These results support the existence of two populations of T lymphocytes in silicosis patients, one resistant to Fas-mediated apoptosis (a self-recognizing long-surviving fraction) and the other one sensitive to silica-induced apoptosis and repeatedly undergoing death and recruitment. |
| 書誌情報 |
en : Kawasaki medical journal
巻 27,
号 3･4,
p. 75-81,
発行日 2001
|
| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2001en/27(3.4)75-81.2001.pdf |
|
識別子タイプ |
URI |
| DOI |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.11482/KMJ27(3.4)75-81.2001.pdf |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
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出版タイプ |
VoR |
KJ00001983884.pdf (580.2 kB)
