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  1. 川崎医学会機関誌
  2. Kawasaki Medical Journal
  3. Vol.28(2002)
  4. No.2・3・4

Research on the H-reflex of Rabbits with Experimental Spinal Cord Injury; Effects of a GABAB Agonist and a GABAB Receptor Agonist Positive Modulator on the H-reflex

https://kwmed.repo.nii.ac.jp/records/517
https://kwmed.repo.nii.ac.jp/records/517
ac26e366-3b9f-4198-b77b-9bd8a5a80141
名前 / ファイル ライセンス アクション
KJ00000010565.pdf KJ00000010565.pdf (1.3 MB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-01-23
タイトル
タイトル Research on the H-reflex of Rabbits with Experimental Spinal Cord Injury; Effects of a GABAB Agonist and a GABAB Receptor Agonist Positive Modulator on the H-reflex
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 ABE, Hiromasa

× ABE, Hiromasa

en ABE, Hiromasa

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著者所属(英)
en
Department of Rehabilitation Medicine, Kawasaki Medical School
キーワード
言語 en
主題Scheme Other
主題 H-reflex
キーワード
言語 en
主題Scheme Other
主題 spinal cord injury
キーワード
言語 en
主題Scheme Other
主題 GABAB receptor agonist
キーワード
言語 en
主題Scheme Other
主題 GABAB receptor agonist positive modulator
抄録(英)
en
The H-reflex is sometimes used for evaluation of spasticity following spinal cord injury (SCI). Since it is difficult to perform any human experimental research related to changes in the H-reflex after the administration of new medicines or after invasive operations, I created an experimental SCI model using rabbits, and compared the waveforms of the H-reflex before and after the creation of SCI. The effects of intrathecal infusion of muscle relaxants on the H-reflex were also investigated. At first, appearance of the H-reflex before and 1 week after creating SCI was observed, and the amplitude ratio of the maximum H-reflex and the maximum M-wave (H/M ratio) was calculated. Then, the effects of baclofen (GABAB receptor agonist) and CGP7930 (GABAB receptor agonist positive modulator) on the H/M ratio of the SCI rabbits were investigated. The H-reflex was evoked by smaller amplitude stimulation after the creation of SCI than before. The H/M ratio after the creation of SCI was significantly higher than before the creation. The mean H/M ratio after infusion of baclofen (10 nmol) was significantly lower than before infusion. Single infusion of CGP7930 had no effect on the H/M ratio. The mean H/M ratio after combined infusion of baclofen (10 nmol) and CGP7930 (1 nmol) was significantly lower than before infusion, and the reduction was more significant than that after single infusion of baclofen. It was ascertained that the increase in the H/M ratio after the creation of SCI is caused by interception of central descending pathways projecting to Ia inhibitory interneurons and that baclofen activated the presynaptic GABAB receptors on Ia afferent terminals. If single infusion of baclofen is not effective in any patients, additional infusion of CGP7930 may be used for the management of severe spasticity in the future.
書誌情報 en : Kawasaki medical journal

巻 28, 号 2・3・4, p. 43-56, 発行日 2002
URL
識別子 http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2002en/28(2.3.4)43-56.2002.pdf
識別子タイプ URI
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.11482/KMJ28(2.3.4)43-56.2002.pdf
ISSN
収録物識別子タイプ PISSN
収録物識別子 0385-0234
ISSN
収録物識別子タイプ EISSN
収録物識別子 2434-3404
雑誌書誌ID
収録物識別子タイプ NCID
収録物識別子 AA00710169
雑誌書誌ID
収録物識別子タイプ NCID
収録物識別子 AA12029005
著者版フラグ
出版タイプ VoR
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