| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
Silica and mineral silicates causing autoimmune diseases |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
LEE, Suni
MATSUZAKI, Hidenori
KUMAGA-TAKEI, Naoko
YAMAMOTO, Shoko
HATAYAMA, Tamayo
YOSHITOME, Kei
NISHIMURA, Yasumitsu
OTSUKI, Takemi
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| 著者所属(英) |
|
|
|
en |
|
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Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
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en |
|
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Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of Hygiene,Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of Hygiene,Kawasaki Medical School |
| キーワード |
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|
言語 |
en |
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主題Scheme |
Other |
|
主題 |
Silica |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Asbestos |
| キーワード |
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|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Autoimmune diseases |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Autoantibody |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Review |
|
言語 |
en |
| 抄録(英) |
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|
en |
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There are many environmental, occupational and medical substances that cause dysregulation of autoimmunity. Among these substances, the effects and causative mechanisms of silica particles and asbestos fibers are discussed in this review. Many epidemiological studies have shown a significant association between silica exposure and the occurrence of autoimmune diseases such as rheumatoid arthritis (RA), systemic sclerosis (SSc), systemic lupus erythematosus (SLE), and anti-neutrophil cytoplasm antibody (ANCA)-related vasculitis. Although the importance of NALP3 inflammasome as the initial immune reaction against silica particles has been recognized, the processes that form the various autoimmune diseases in silica-exposed patients remain unclear. Silica can activate various immune cells and cause an unbalance of regulatory T cells, responder T cells and T helper 17 cells, which might be key factors in understanding the silica-induced autoimmune alteration. In contrast, asbestos exposure shows a smaller association with autoimmune diseases. However, interesting findings have been reported regarding anti-endothelial and mesothelial cell antibodies detected in asbestos-exposed patients. Further investigations may contribute to elucidation of the mechanisms involved in environmental factor-induced modification of autoimmunity. |
| 書誌情報 |
en : Kawasaki medical journal
巻 42,
号 1,
p. 15-24,
発行日 2016
|
| URL |
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|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2016en/KMJ-E42(1)15.pdf |
|
識別子タイプ |
URI |
| DOI |
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識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.11482/KMJ-E42(1)15 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 雑誌書誌ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
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出版タイプ |
VoR |
KJ00010236139.pdf (758.2 kB)
