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The notch ligand Delta-like ligand 4 (DLL4) is induced by VEGF and acts as a negative regulator of tumor angiogenesis by reducing the numbers of non-productive sprouting vessels. Several reports have shown the prognostic role of VEGF expression in non-small cell lung cancer. However, the correlation between VEGF and DLL4 expression and their clinical significance in non-small cell lung cancer remains unclear. The aim of this study was to analyze the correlation between the expression of VEGF/DLL4 and the clinicopathological background. Fifty-eight patients with lung adenocarcinomas measuring less than 3 cm in diameter who underwent surgical resection at Kawasaki Medical School Hospital from 2008 to 2010 were enrolled in this study. The expressions of VEGF, DLL4, CD31, and Ki-67 were analyzed using immunohistochemical staining. The tumor cells were VEGF-positive in 44 patients (75.9%) and DLL4-positive in 41 patients (70.7%). No statistically significant association was observed between the patients\u0027 characteristics and VEGF/DLL4 expression. A high VEGF expression level tended to be associated with a high DLL4 expression level (P = 0.050, r = 0.258). The mean Ki-67 index was significantly lower in the patients with high VEGF expression (9.5 vs. 18.2, P = 0.011), but no significant difference was observed when patients were compared according to their DLL4 expression levels (11.8 vs. 11.0, P = 0.804). The mean Ki-67 index was higher in the VEGF_\u003clow\u003e DLL4_\u003clow\u003e patients than in the VEGFhigh DLL4high patients by a marginally significant difference (20.1 vs. 10.9 P = 0.056). The 3-year recurrence-free survival rates of the VEGF_\u003chigh\u003e/DLL4_\u003chigh\u003e and the VEGF_\u003clow\u003e/DLL4_\u003clow\u003e patients were 83.3% and 35.7%, respectively. The prognosis of the VEGF_\u003chigh\u003e/DLL4_\u003chigh\u003e patients was significantly better than that of the VEGF_\u003clow\u003e/DLL4_\u003clow\u003e patients (P = 0.032). To investigate the significance of the difference in tumor proliferation and prognosis between the VEGF_\u003chigh\u003e/DLL4_\u003chigh\u003e and the VEGF_\u003clow\u003e/DLL4_\u003clow\u003e patients, we evaluated the morphologic effect of VEGF/DLL4 expression on the intratumoral capillaries by counting the number of capillaries and calculating the luminal area (μm^2). No significant differences were seen between either the VEGF or DLL4 expression levels and the mean number of intratumoral capillaries or the luminal area (μm^2). 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Clinical significance of vascular endothelial growth factor and Delta-like ligand 4 in small pulmonary adenocarcinoma
https://kwmed.repo.nii.ac.jp/records/568
https://kwmed.repo.nii.ac.jp/records/5686deb19ab-66de-4fa0-9fbe-c8f0c151de13
名前 / ファイル | ライセンス | アクション |
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KJ00009303659.pdf (422.8 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-01-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical significance of vascular endothelial growth factor and Delta-like ligand 4 in small pulmonary adenocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yasuda, Koichiro
× Yasuda, Koichiro× Nakata, Masao× Nojima, Yuji× Maeda, Ai× Yukawa, Takuro× Saisho, Shinsuke× Okita, Riki× Shimizu, Katsuhiko |
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著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Non-small cell lung cancer | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Adenocarcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | VEGF | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | DLL4 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Angiogenesis | |||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
抄録(英) | ||||||
en | ||||||
Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. The notch ligand Delta-like ligand 4 (DLL4) is induced by VEGF and acts as a negative regulator of tumor angiogenesis by reducing the numbers of non-productive sprouting vessels. Several reports have shown the prognostic role of VEGF expression in non-small cell lung cancer. However, the correlation between VEGF and DLL4 expression and their clinical significance in non-small cell lung cancer remains unclear. The aim of this study was to analyze the correlation between the expression of VEGF/DLL4 and the clinicopathological background. Fifty-eight patients with lung adenocarcinomas measuring less than 3 cm in diameter who underwent surgical resection at Kawasaki Medical School Hospital from 2008 to 2010 were enrolled in this study. The expressions of VEGF, DLL4, CD31, and Ki-67 were analyzed using immunohistochemical staining. The tumor cells were VEGF-positive in 44 patients (75.9%) and DLL4-positive in 41 patients (70.7%). No statistically significant association was observed between the patients' characteristics and VEGF/DLL4 expression. A high VEGF expression level tended to be associated with a high DLL4 expression level (P = 0.050, r = 0.258). The mean Ki-67 index was significantly lower in the patients with high VEGF expression (9.5 vs. 18.2, P = 0.011), but no significant difference was observed when patients were compared according to their DLL4 expression levels (11.8 vs. 11.0, P = 0.804). The mean Ki-67 index was higher in the VEGF_<low> DLL4_<low> patients than in the VEGFhigh DLL4high patients by a marginally significant difference (20.1 vs. 10.9 P = 0.056). The 3-year recurrence-free survival rates of the VEGF_<high>/DLL4_<high> and the VEGF_<low>/DLL4_<low> patients were 83.3% and 35.7%, respectively. The prognosis of the VEGF_<high>/DLL4_<high> patients was significantly better than that of the VEGF_<low>/DLL4_<low> patients (P = 0.032). To investigate the significance of the difference in tumor proliferation and prognosis between the VEGF_<high>/DLL4_<high> and the VEGF_<low>/DLL4_<low> patients, we evaluated the morphologic effect of VEGF/DLL4 expression on the intratumoral capillaries by counting the number of capillaries and calculating the luminal area (μm^2). No significant differences were seen between either the VEGF or DLL4 expression levels and the mean number of intratumoral capillaries or the luminal area (μm^2). In conclusion, VEGF_<low>/DLL4_<low> patients with small pulmonary adenocarcinoma had a significantly poorer prognosis, although no significant difference in a morphological evaluation of the capillaries was seen between VEGF_<high>/DLL4_<high> and VEGF_<low>/DLL4_<low> patients. | ||||||
書誌情報 |
en : Kawasaki medical journal 巻 40, 号 1, p. 23-31, 発行日 2014 |
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URL | ||||||
識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2014en/KMJ-E40(1)23.pdf | |||||
識別子タイプ | URI | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-E40(1)23 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0385-0234 | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2434-3404 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12685295 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12029005 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |