| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
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|
タイトル |
Clinical significance of vascular endothelial growth factor and Delta-like ligand 4 in small pulmonary adenocarcinoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yasuda, Koichiro
Nakata, Masao
Nojima, Yuji
Maeda, Ai
Yukawa, Takuro
Saisho, Shinsuke
Okita, Riki
Shimizu, Katsuhiko
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| 著者所属(英) |
|
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|
en |
|
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Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
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en |
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Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
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en |
|
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Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
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Department of General Thoracic Surgery, Kawasaki Medical School |
| キーワード |
|
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言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Non-small cell lung cancer |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Adenocarcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
VEGF |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
DLL4 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Angiogenesis |
| 記事種別(日) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 抄録(英) |
|
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|
en |
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Vascular endothelial growth factor (VEGF) plays a key role in tumor angiogenesis. The notch ligand Delta-like ligand 4 (DLL4) is induced by VEGF and acts as a negative regulator of tumor angiogenesis by reducing the numbers of non-productive sprouting vessels. Several reports have shown the prognostic role of VEGF expression in non-small cell lung cancer. However, the correlation between VEGF and DLL4 expression and their clinical significance in non-small cell lung cancer remains unclear. The aim of this study was to analyze the correlation between the expression of VEGF/DLL4 and the clinicopathological background. Fifty-eight patients with lung adenocarcinomas measuring less than 3 cm in diameter who underwent surgical resection at Kawasaki Medical School Hospital from 2008 to 2010 were enrolled in this study. The expressions of VEGF, DLL4, CD31, and Ki-67 were analyzed using immunohistochemical staining. The tumor cells were VEGF-positive in 44 patients (75.9%) and DLL4-positive in 41 patients (70.7%). No statistically significant association was observed between the patients' characteristics and VEGF/DLL4 expression. A high VEGF expression level tended to be associated with a high DLL4 expression level (P = 0.050, r = 0.258). The mean Ki-67 index was significantly lower in the patients with high VEGF expression (9.5 vs. 18.2, P = 0.011), but no significant difference was observed when patients were compared according to their DLL4 expression levels (11.8 vs. 11.0, P = 0.804). The mean Ki-67 index was higher in the VEGF_<low> DLL4_<low> patients than in the VEGFhigh DLL4high patients by a marginally significant difference (20.1 vs. 10.9 P = 0.056). The 3-year recurrence-free survival rates of the VEGF_<high>/DLL4_<high> and the VEGF_<low>/DLL4_<low> patients were 83.3% and 35.7%, respectively. The prognosis of the VEGF_<high>/DLL4_<high> patients was significantly better than that of the VEGF_<low>/DLL4_<low> patients (P = 0.032). To investigate the significance of the difference in tumor proliferation and prognosis between the VEGF_<high>/DLL4_<high> and the VEGF_<low>/DLL4_<low> patients, we evaluated the morphologic effect of VEGF/DLL4 expression on the intratumoral capillaries by counting the number of capillaries and calculating the luminal area (μm^2). No significant differences were seen between either the VEGF or DLL4 expression levels and the mean number of intratumoral capillaries or the luminal area (μm^2). In conclusion, VEGF_<low>/DLL4_<low> patients with small pulmonary adenocarcinoma had a significantly poorer prognosis, although no significant difference in a morphological evaluation of the capillaries was seen between VEGF_<high>/DLL4_<high> and VEGF_<low>/DLL4_<low> patients. |
| 書誌情報 |
en : Kawasaki medical journal
巻 40,
号 1,
p. 23-31,
発行日 2014
|
| URL |
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|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/2014en/KMJ-E40(1)23.pdf |
|
識別子タイプ |
URI |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.11482/KMJ-E40(1)23 |
| ISSN |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
0385-0234 |
| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
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|
出版タイプ |
VoR |
KJ00009303659.pdf (422.8 kB)
