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3H-Spiroperidol (Spiperone) Binding Sites in Rat Adrenal Glomerulosa Cells
https://kwmed.repo.nii.ac.jp/records/181
https://kwmed.repo.nii.ac.jp/records/1815e319076-25ab-4466-8f2a-73410dab7f00
名前 / ファイル | ライセンス | アクション |
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KJ00010221579.pdf (507.8 kB)
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Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-01-23 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 3H-Spiroperidol (Spiperone) Binding Sites in Rat Adrenal Glomerulosa Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
MATSUKI, Michihiro
× MATSUKI, Michihiro× NISHIDA, Seikoh× HORINO, Masaharu× ADACHI, Noriko× YONEDA, Masaya× OYAMA, Hideki |
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著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Medicine, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Medicine, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Medicine, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Medicine, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Medicine, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Division of Endocrinology, Department of Medicine, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 3H-spiroperidol | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Dopamine receptor | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Rat adrenal glomerulosa cells | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Original Article | |||||
抄録(英) | ||||||
en | ||||||
3H-spiperone, a dopaminergic antagonist, was used to study binding sites in rat adrenal glomerulosa membrane. The equilibrium dissociation constant (Kd) and binding capacity for 3H-spiperone binding were 2.2 nM and 268 fmol/mg protein, respectively. Determination of the Kd by kinetic studies provided a value of 2.6 nM, which corresponded closely to the Kd estimated by equilibrium studies. In a study of the subcellular distribution of dopamine receptors in adrenal glomerulosa cells, 3H-spiperone binding activity at the interface of density 1.14 to 1.16 accounted for 60% of the total activity in all fractions. These dopaminergic binding sites in adrenal glomerulosa cells may modulate aldosterone secretion induced by antidopaminergic agents. | ||||||
書誌情報 |
en : Kawasaki medical journal 巻 12, 号 2, p. 83-87, 発行日 1986 |
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URL | ||||||
識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1986en/12(2)83-87.1986.pdf | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1986en/12(2)83-87.1986.pdf | |||||
識別子タイプ | URI | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-E12(2)83 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0385-0234 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2434-3404 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00710169 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12029005 |