| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
|
|
タイトル |
3H-Spiroperidol (Spiperone) Binding Sites in Rat Adrenal Glomerulosa Cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
MATSUKI, Michihiro
NISHIDA, Seikoh
HORINO, Masaharu
ADACHI, Noriko
YONEDA, Masaya
OYAMA, Hideki
|
| 著者所属(英) |
|
|
|
en |
|
|
Division of Endocrinology, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Endocrinology, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Endocrinology, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Endocrinology, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Endocrinology, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Endocrinology, Department of Medicine, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
3H-spiroperidol |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Dopamine receptor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rat adrenal glomerulosa cells |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
|
|
|
en |
|
|
3H-spiperone, a dopaminergic antagonist, was used to study binding sites in rat adrenal glomerulosa membrane. The equilibrium dissociation constant (Kd) and binding capacity for 3H-spiperone binding were 2.2 nM and 268 fmol/mg protein, respectively. Determination of the Kd by kinetic studies provided a value of 2.6 nM, which corresponded closely to the Kd estimated by equilibrium studies. In a study of the subcellular distribution of dopamine receptors in adrenal glomerulosa cells, 3H-spiperone binding activity at the interface of density 1.14 to 1.16 accounted for 60% of the total activity in all fractions. These dopaminergic binding sites in adrenal glomerulosa cells may modulate aldosterone secretion induced by antidopaminergic agents. |
| 書誌情報 |
en : Kawasaki medical journal
巻 12,
号 2,
p. 83-87,
発行日 1986
|
| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1986en/12(2)83-87.1986.pdf |
|
識別子タイプ |
URI |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E12(2)83 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010221579.pdf (507.8 kB)
