WEKO3
アイテム
{"_buckets": {"deposit": "de664053-1d25-4c00-9454-301fd374c9ce"}, "_deposit": {"created_by": 3, "id": "3005", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "3005"}, "status": "published"}, "_oai": {"id": "oai:kwmed.repo.nii.ac.jp:00003005", "sets": ["801"]}, "author_link": ["130970", "130979", "130973", "130975", "130966", "130976", "130967", "130977", "130971", "130972", "130974", "130969", "130968", "130978"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "54", "bibliographicPageStart": "47", "bibliographicVolumeNumber": "47", "bibliographic_titles": [{}, {"bibliographic_title": "Kawasaki medical journal", "bibliographic_titleLang": "en"}]}]}, "item_10001_description_34": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Regular Article", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Kawasaki Medical Society"}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.11482/KMJ-E202147047", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147047.pdf"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147047.pdf", "subitem_relation_type_select": "URI"}}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12685295", "subitem_source_identifier_type": "NCID"}, {"subitem_source_identifier": "AA12029005", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03850234", "subitem_source_identifier_type": "ISSN"}, {"subitem_source_identifier": "24343404", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_32": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "General Medical Center Research Unit, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "General Medical Center Research Unit, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "SBI Pharmaceuticals Co., Ltd."}, {"subitem_text_language": "en", "subitem_text_value": "SBI Pharmaceuticals Co., Ltd."}, {"subitem_text_language": "en", "subitem_text_value": "Department of Anesthesiology \u0026 Intensive Care Medicine 3, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Anesthesiology \u0026 Intensive Care Medicine 3, Kawasaki Medical School"}, {"subitem_text_language": "en", "subitem_text_value": "Department of General Surgery, Kawasaki Medical School"}]}, "item_10001_textarea_5": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_textarea_language": "en", "subitem_textarea_value": " An effective anti-cancer chemotherapy regimen can cause adverse events such as antineoplastic drug-induced oxidative stress in tissues. When hemeoxygenase-1 (HO1) is induced in tissues under oxidative stress, a tissue protective effect is observed. The non-proteinogenic amino acid 5-aminolevulinic acid (5-ALA) induces HO-1 in normal tissue and is hypothesized to provide an intestinal epithelial protective effect against drug-induced gastrointestinal mucosal disorders such as diarrhea and stomatitis. To validate this hypothesis, we introduced organoid culture from mouse intestinal epithelium. Using this organoid culture system, SN-38, the active metabolite of the antineoplastic drug irinotecan which is known to induce gastrointestinal mucosal disorders, was administered with and without 5-ALA to investigate the cytotoxic and protective effects of HO-1 suppression and expression. In normal intestinal epithelial cells, HO-1 induction by 5-ALA was observed. HO-1 expression was suppressed by the administration of SN-38 in the absence of 5-ALA, but was maintained by the co-administration of 5-ALA. In the mouse intestinal organoids, the same administration of 5-ALA induced HO-1 expression. When SN-38 was administered to the organoids, a cell death signal was expressed with an oxidative stress response, but the co-administration of 5-ALA induced HO-1 expression and cell death was decreased. The induction of HO-1 expression by 5-ALA administration suppresses intestinal epithelial cell death mediated by oxidative stress caused by antineoplastic drugs and is a potential new intestinal epithelial protective therapy against drug-induced gastrointestinal mucosal injury."}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "TAKAOKA, Munenori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130966", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ISHIDA, Naomasa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130967", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IWAI, Miki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130968", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TATSUTA, Yoshiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KOSAKA, Rie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130970", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YOKOTA, Etsuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130971", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MIYAKE, Noriko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130972", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUKAZAWA, Takuya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130973", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MATSUBARA, Masaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130974", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TANAKA, Tohru", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130975", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "NAKAJIMA, Motowo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130976", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IKEMOTO, Naoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130977", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OCHIAI, Yoko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130978", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMATSUJI, Tomoki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "130979", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-04-01"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KMJ-E202147047.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "PDF", "url": "https://kwmed.repo.nii.ac.jp/record/3005/files/KMJ-E202147047.pdf"}, "version_id": "e249aa59-5b55-41d0-a0d4-4b5ba47e489b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "5-aminolevulinic acid", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Hemeoxygenese-1", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Oxidative stresIntestinal mucosal injury", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chemotherapy", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "3", "path": ["801"], "permalink_uri": "https://kwmed.repo.nii.ac.jp/records/3005", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-04-01"}, "publish_date": "2022-04-01", "publish_status": "0", "recid": "3005", "relation": {}, "relation_version_is_last": true, "title": ["A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa"], "weko_shared_id": -1}
A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa
https://kwmed.repo.nii.ac.jp/records/3005
https://kwmed.repo.nii.ac.jp/records/3005b50cb20d-ac50-440d-9f3d-36da70726ff4
名前 / ファイル | ライセンス | アクション |
---|---|---|
PDF (3.2 MB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2022-04-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
TAKAOKA, Munenori
× TAKAOKA, Munenori× ISHIDA, Naomasa× IWAI, Miki× TATSUTA, Yoshiko× KOSAKA, Rie× YOKOTA, Etsuko× MIYAKE, Noriko× FUKAZAWA, Takuya× MATSUBARA, Masaki× TANAKA, Tohru× NAKAJIMA, Motowo× IKEMOTO, Naoto× OCHIAI, Yoko× YAMATSUJI, Tomoki |
|||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
General Medical Center Research Unit, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
General Medical Center Research Unit, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
SBI Pharmaceuticals Co., Ltd. | ||||||
著者所属(英) | ||||||
en | ||||||
SBI Pharmaceuticals Co., Ltd. | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Anesthesiology & Intensive Care Medicine 3, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Anesthesiology & Intensive Care Medicine 3, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Surgery, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | 5-aminolevulinic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Hemeoxygenese-1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Oxidative stresIntestinal mucosal injury | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Chemotherapy | |||||
抄録(英) | ||||||
en | ||||||
An effective anti-cancer chemotherapy regimen can cause adverse events such as antineoplastic drug-induced oxidative stress in tissues. When hemeoxygenase-1 (HO1) is induced in tissues under oxidative stress, a tissue protective effect is observed. The non-proteinogenic amino acid 5-aminolevulinic acid (5-ALA) induces HO-1 in normal tissue and is hypothesized to provide an intestinal epithelial protective effect against drug-induced gastrointestinal mucosal disorders such as diarrhea and stomatitis. To validate this hypothesis, we introduced organoid culture from mouse intestinal epithelium. Using this organoid culture system, SN-38, the active metabolite of the antineoplastic drug irinotecan which is known to induce gastrointestinal mucosal disorders, was administered with and without 5-ALA to investigate the cytotoxic and protective effects of HO-1 suppression and expression. In normal intestinal epithelial cells, HO-1 induction by 5-ALA was observed. HO-1 expression was suppressed by the administration of SN-38 in the absence of 5-ALA, but was maintained by the co-administration of 5-ALA. In the mouse intestinal organoids, the same administration of 5-ALA induced HO-1 expression. When SN-38 was administered to the organoids, a cell death signal was expressed with an oxidative stress response, but the co-administration of 5-ALA induced HO-1 expression and cell death was decreased. The induction of HO-1 expression by 5-ALA administration suppresses intestinal epithelial cell death mediated by oxidative stress caused by antineoplastic drugs and is a potential new intestinal epithelial protective therapy against drug-induced gastrointestinal mucosal injury. | ||||||
書誌情報 |
en : Kawasaki medical journal 巻 47, p. 47-54, 発行日 2021 |
|||||
出版者 | ||||||
出版者 | Kawasaki Medical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03850234 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 24343404 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12685295 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12029005 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-E202147047 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Regular Article | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147047.pdf | |||||
関連名称 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147047.pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |