| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-04-01 |
| タイトル |
|
|
タイトル |
A potential protective effect of 5-aminolevulinic acid against anticancer drug-induced damage to intestinal mucosa |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
TAKAOKA, Munenori
ISHIDA, Naomasa
IWAI, Miki
TATSUTA, Yoshiko
KOSAKA, Rie
YOKOTA, Etsuko
MIYAKE, Noriko
FUKAZAWA, Takuya
MATSUBARA, Masaki
TANAKA, Tohru
NAKAJIMA, Motowo
IKEMOTO, Naoto
OCHIAI, Yoko
YAMATSUJI, Tomoki
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
General Medical Center Research Unit, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
General Medical Center Research Unit, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
SBI Pharmaceuticals Co., Ltd. |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
SBI Pharmaceuticals Co., Ltd. |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Anesthesiology & Intensive Care Medicine 3, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Anesthesiology & Intensive Care Medicine 3, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Surgery, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
5-aminolevulinic acid |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hemeoxygenese-1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Oxidative stresIntestinal mucosal injury |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Chemotherapy |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
An effective anti-cancer chemotherapy regimen can cause adverse events such as antineoplastic drug-induced oxidative stress in tissues. When hemeoxygenase-1 (HO1) is induced in tissues under oxidative stress, a tissue protective effect is observed. The non-proteinogenic amino acid 5-aminolevulinic acid (5-ALA) induces HO-1 in normal tissue and is hypothesized to provide an intestinal epithelial protective effect against drug-induced gastrointestinal mucosal disorders such as diarrhea and stomatitis. To validate this hypothesis, we introduced organoid culture from mouse intestinal epithelium. Using this organoid culture system, SN-38, the active metabolite of the antineoplastic drug irinotecan which is known to induce gastrointestinal mucosal disorders, was administered with and without 5-ALA to investigate the cytotoxic and protective effects of HO-1 suppression and expression. In normal intestinal epithelial cells, HO-1 induction by 5-ALA was observed. HO-1 expression was suppressed by the administration of SN-38 in the absence of 5-ALA, but was maintained by the co-administration of 5-ALA. In the mouse intestinal organoids, the same administration of 5-ALA induced HO-1 expression. When SN-38 was administered to the organoids, a cell death signal was expressed with an oxidative stress response, but the co-administration of 5-ALA induced HO-1 expression and cell death was decreased. The induction of HO-1 expression by 5-ALA administration suppresses intestinal epithelial cell death mediated by oxidative stress caused by antineoplastic drugs and is a potential new intestinal epithelial protective therapy against drug-induced gastrointestinal mucosal injury. |
| 書誌情報 |
en : Kawasaki medical journal
巻 47,
p. 47-54,
発行日 2021
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03850234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202147047 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147047.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (3.2 MB)
