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The biological Characteristics of Solid Components are Different between Part-Solid-Type and Solid-Type in Lung Adenocarcinoma
https://kwmed.repo.nii.ac.jp/records/3010
https://kwmed.repo.nii.ac.jp/records/301079e73f89-aa77-4de0-8239-8537e3cb2e74
名前 / ファイル | ライセンス | アクション |
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PDF (3.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2022-04-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The biological Characteristics of Solid Components are Different between Part-Solid-Type and Solid-Type in Lung Adenocarcinoma | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
SAISHO, Shinsuke
× SAISHO, Shinsuke× SHIMIZU, Katsuhiko× NOJIMA, Yuji× KUROSAKI, Takeshi× NAKATA, Masao |
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著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
著者所属(英) | ||||||
en | ||||||
Department of General Thoracic Surgery, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Solid-type lung adenocarcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Part-solid-type lung adenocarcinoma | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Solid component | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ki-67 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | PD-L1 | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | CD8+ TIL | |||||
抄録(英) | ||||||
en | ||||||
Numerous studies have been conducted to determine the clinical significance of the ground-glass opacity and solid-components in lung adenocarcinomas, however, few biological analyses of the two components have been carried out. This study was aimed at clarifying the biological characteristics of solid components in part-solid-type and solid-type lung adenocarcinomas. Data of a total of 112 cases of cT1b/cN0M0 lung adenocarcinoma treated by surgical resection were analyzed. We compared clinicopathological characteristics and prognosis between part-solid-type and solid-type tumors. In addition, we performed immunohistochemical analysis to determine the Ki-67 labeling index (LI), programmed cell death-1 ligand 1 (PD-L1) expression status, and CD8-positive tumor-infiltrating T lymphocyte (CD8+ TIL) count for the solid component of each tumor. Five-year recurrence-free survival (RFS) risks were significantly worse for patients with solid-type tumor than for those with part-solidtype tumor (51.7% vs. 83.2%; p < 0.001). The percentages of lymphovascular invasion, lymph node metastasis, high Ki-67 LI, and high PD-L1 expression were higher in the patient group with solid-type tumors. Univariate analysis identified Ki-67 LI, PD-L1 expression status, and CD8+ TIL count were identified as predictors of RFS in the entire subject population. Separate analyses in the two groups identified only the Ki-67 LI as an independent predictor of the RFS in the group with part-solid-type tumors, whereas in the group with solid-type tumors, the PDL1 expression status and CD8+ TIL count were identified as independent predictors of the RFS. Clear differences in the biological characteristics of the solid-component were identified between part-solid-type and solid-type lung adenocarcinomas. | ||||||
書誌情報 |
en : Kawasaki medical journal 巻 47, p. 85-97, 発行日 2021 |
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出版者 | ||||||
出版者 | Kawasaki Medical Society | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03850234 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 24343404 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12685295 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA12029005 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-E202147085 | |||||
記事種別(英) | ||||||
内容記述タイプ | Other | |||||
内容記述 | Regular Article | |||||
関連サイト | ||||||
識別子タイプ | URI | |||||
関連識別子 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147085.pdf | |||||
関連名称 | https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147085.pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |