| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2022-04-01 |
| タイトル |
|
|
タイトル |
The biological Characteristics of Solid Components are Different between Part-Solid-Type and Solid-Type in Lung Adenocarcinoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
SAISHO, Shinsuke
SHIMIZU, Katsuhiko
NOJIMA, Yuji
KUROSAKI, Takeshi
NAKATA, Masao
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Thoracic Surgery, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of General Thoracic Surgery, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Solid-type lung adenocarcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Part-solid-type lung adenocarcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Solid component |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Ki-67 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
PD-L1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CD8+ TIL |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
Numerous studies have been conducted to determine the clinical significance of the ground-glass opacity and solid-components in lung adenocarcinomas, however, few biological analyses of the two components have been carried out. This study was aimed at clarifying the biological characteristics of solid components in part-solid-type and solid-type lung adenocarcinomas. Data of a total of 112 cases of cT1b/cN0M0 lung adenocarcinoma treated by surgical resection were analyzed. We compared clinicopathological characteristics and prognosis between part-solid-type and solid-type tumors. In addition, we performed immunohistochemical analysis to determine the Ki-67 labeling index (LI), programmed cell death-1 ligand 1 (PD-L1) expression status, and CD8-positive tumor-infiltrating T lymphocyte (CD8+ TIL) count for the solid component of each tumor. Five-year recurrence-free survival (RFS) risks were significantly worse for patients with solid-type tumor than for those with part-solidtype tumor (51.7% vs. 83.2%; p < 0.001). The percentages of lymphovascular invasion, lymph node metastasis, high Ki-67 LI, and high PD-L1 expression were higher in the patient group with solid-type tumors. Univariate analysis identified Ki-67 LI, PD-L1 expression status, and CD8+ TIL count were identified as predictors of RFS in the entire subject population. Separate analyses in the two groups identified only the Ki-67 LI as an independent predictor of the RFS in the group with part-solid-type tumors, whereas in the group with solid-type tumors, the PDL1 expression status and CD8+ TIL count were identified as independent predictors of the RFS. Clear differences in the biological characteristics of the solid-component were identified between part-solid-type and solid-type lung adenocarcinomas. |
| 書誌情報 |
en : Kawasaki medical journal
巻 47,
p. 85-97,
発行日 2021
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
03850234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12685295 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202147085 |
| 記事種別(英) |
|
|
内容記述 |
Regular Article |
|
言語 |
en |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2021en/KMJ-E202147085.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (3.5 MB)
