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Structural Analysis of Human Hemoglobin Variants by Molecular Secondary Ion Mass Spectrometry
https://kwmed.repo.nii.ac.jp/records/274
https://kwmed.repo.nii.ac.jp/records/27417b1dddd-917f-4826-851e-297e74fa8304
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
KJ00010214039.pdf (480.0 kB)
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| Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2017-01-23 | |||||||||
| タイトル | ||||||||||
| タイトル | Structural Analysis of Human Hemoglobin Variants by Molecular Secondary Ion Mass Spectrometry | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
HIDAKA, Kazuo
× HIDAKA, Kazuo
× IUCHI, Iwao
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| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Biochemistry, Kawasaki Medical School | ||||||||||
| 著者所属(英) | ||||||||||
| en | ||||||||||
| Department of Biochemistry, Kawasaki Medical School | ||||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Secondary ion mass spectrometry -SIMS- | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Hb Ube-2 | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Hb G-Coushatta | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | Hb Himeji | |||||||||
| 記事種別(英) | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | Original Article | |||||||||
| 言語 | en | |||||||||
| 抄録(英) | ||||||||||
| en | ||||||||||
| Chemically purified abnormal peptides, α62-76 of Hb Ube-2, βT-3 of Hb G-Coushatta, αT-7 of Hb J-Norfolk and βT-1 of Hb Himeji, were subjected to molecular secondary ion mass spectrometry (SIMS). These peptides were identified by the mass number of their protonated molecular ion (M+H)+ and their amino acid sequence was confirmed by a series of the mass number of fragmented ions released by a stepwise removal from their C-terminus. Amino acid substitution of α68 Asn→Asp in Hb Ube-2, β22 Gln→ Ala in Hb G-Coushatta and α51 Gly→Asp in Hb J-Norfolk was successfully determined and a questionable Hb variant, tentatively called Hb Himeji (β140 Ala→ Asp) was proven to have a significant amount of the additive of the glycated N-terminus of the βT-1 peptide. | ||||||||||
| 書誌情報 |
en : Kawasaki medical journal 巻 15, 号 2, p. 53-58, 発行日 1989 |
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| URL | ||||||||||
| 識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1989en/15(2)53-58.1989.pdf | |||||||||
| 識別子タイプ | URI | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.11482/KMJ-E15(2)53 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0385-0234 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2434-3404 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA00710169 | |||||||||
| 雑誌書誌ID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12029005 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
