| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-03-10 |
| タイトル |
|
|
タイトル |
Severe thrombocytopenia and maculopapular erythema-induced by regorafenib in a patient with advanced gastrointestinal stromal tumor |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
YAMAMURA, Masahiro
HIRAI, Toshihiro
OKAWAKI, Makoto
OKA, Daigo
NISHIMURA, Hirotake
YAMAGUCHI, Yoshiyuki
|
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Clinical Oncology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Mitsugi General Hospital |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Clinical Oncology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Dermatology |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Pathology, Kawasaki Medical School |
| 著者所属(英) |
|
|
言語 |
en |
|
値 |
Department of Clinical Oncology, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Regorafenib |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Thrombocytopenia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Cutaneous adverse reactions |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Maculopapular erythema |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Gastrointestinal stromal tumor\n |
| 抄録(英) |
|
|
言語 |
en |
|
値 |
A 28-year-old Japanese male was diagnosed with a gastrointestinal stromal tumor and multiple liver metastases at 23 years of age underwent gastrectomy and partial hepatectomy. At 27 year of age, multiple liver metastases and peritoneal dissemination were observed and the patient was switched to sunitinib. Approximately, one year later, the liver metastases worsened, and the patient was switched to regorafenib. Fatigue and palmar-plantar erythrodysesthesia syndrome occurred seven days after starting regorafenib, and thrombocytopenia occurred nine days later. Eleven days later, small erythema with fever and erythematous papules appeared throughout the body; therefore regorafenib was discontinued, and oral administration of steroids was initiated accordingly. After 17 days, platelets count decreased to 14,000/μL, prompting platelet transfusion. Maculopapular erythema was diagnosed based on the skin findings and histopathological examination. Oral and topical steroids were initiated and the maculopapular eruption gradually improved. A drug hypersensitivity reaction to regorafenib was diagnosed and treatment was discontinued, after which the patient entered a clinical trial for a new drug. We encountered a case of marked thrombocytopenia and maculopapular erythema during the early stages of regorafenib treatment. Regorafenib occasionally causes serious adverse events; therefore, careful observation and prompt treatment are necessary. |
| 書誌情報 |
en : Kawasaki medical journal
巻 48,
p. 183-189,
発行日 2022
|
| 出版者 |
|
|
出版者 |
Kawasaki Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
24343404 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E202248183 |
| 記事種別(英) |
|
|
内容記述 |
Case Report |
|
言語 |
en |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://igakkai.kms-igakkai.com/wp/wp-content/uploads/2022en/KMJ-E202248183.pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
PDF (2.3 MB)
