WEKO3
アイテム
{"_buckets": {"deposit": "a3b1ccbc-d994-4292-b952-29143b19930e"}, "_deposit": {"created_by": 25, "id": "601", "owners": [25], "pid": {"revision_id": 0, "type": "depid", "value": "601"}, "status": "published"}, "_oai": {"id": "oai:kwmed.repo.nii.ac.jp:00000601", "sets": ["430"]}, "author_link": ["120012", "120013"], "item_1694495855422": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_type": "VoR"}]}, "item_3_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1987", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "132", "bibliographicPageStart": "128", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "川崎医学会誌", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Kawasaki medical journal", "bibliographic_titleLang": "en"}]}]}, "item_3_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "2", "subitem_description_type": "Other"}]}, "item_3_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00009816479", "subitem_description_type": "Other"}]}, "item_3_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_3_identifier_14": {"attribute_name": "URL", "attribute_value_mlt": [{"subitem_identifier_type": "URI", "subitem_identifier_uri": "http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987/KMJ13(2)128-132.1987.pdf"}]}, "item_3_relation_20": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.11482/KMJ-J13(2)128 ", "subitem_relation_type_select": "DOI"}}]}, "item_3_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00045593", "subitem_source_identifier_type": "NCID"}, {"subitem_source_identifier": "AN12940574", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0386-5924", "subitem_source_identifier_type": "PISSN"}, {"subitem_source_identifier": "2758-089X", "subitem_source_identifier_type": "EISSN"}]}, "item_3_text_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_text_language": "ja-Kana", "subitem_text_value": "ノルアドレナリン カンジュセイ アデニルサン シクラーゼ ニオヨボス リチウム マンセイ トウヨ ノ コウカ"}]}, "item_3_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_language": "ja", "subitem_text_value": "川崎医科大学精神科"}]}, "item_3_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Psychiatry, Kawasaki Medical School"}]}, "item_3_textarea_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_textarea_language": "ja", "subitem_textarea_value": "ノルアドレナリン受容体に連関したアデニル酸シクラーゼの感受性に及ぼすリチウム慢性投与の効果を若年ラットの前頭皮質と海馬の組織スライスを用いて検討した.その結果,前頭皮質ではリチウム慢性投与によってノルアドレナリン刺激による組織スライスのcyclic AMP増加量は有意に抑制された(p\u003c0.001).なお,血清リチウム濃度は0.54mEq/lであった.したがって,リチウムの抗うつメカニズムはノルアドレナリン感受性アデニル酸シクラーゼの感受性阻害作用と何らかの関連性があるものと推察できる."}]}, "item_3_textarea_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_textarea_language": "en", "subitem_textarea_value": "The effect of chronic administration of lithium on noradrenaline-sensitive adenylate cyclase was examined. The serum lithium level was 0.54mEq/l. Cyclic AMP accumulation in a slice of the frontal cortex was significantly inhibited by lithium (p\u003c0.001). It is suggested that the antidepressive mechanism of lithium is somewhat related to the effect of inhibition of the noradrenaline sensitivity of adenylate cyclase in the frontal cortex."}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "笹野, 友寿", "creatorNameLang": "ja"}, {"creatorName": "ササノ, トモヒサ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "120012", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasano, Tomohisa", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "120013", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-01-23"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00009816479.pdf", "filesize": [{"value": "445.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 445700.0, "url": {"label": "KJ00009816479.pdf", "objectType": "fulltext", "url": "https://kwmed.repo.nii.ac.jp/record/601/files/KJ00009816479.pdf"}, "version_id": "fd43f1e5-a354-4a83-9c79-5d80daa20913"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Noradrenaline-sensitive adenylate cyclase", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Lithium", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "ノルアドレナリン感受性アデニル酸シクラーゼに及ぼすリチウム慢性投与の効果", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ノルアドレナリン感受性アデニル酸シクラーゼに及ぼすリチウム慢性投与の効果", "subitem_title_language": "ja"}, {"subitem_title": "Effect of Chronic Lithium Administration on Noradrenaline-Sensitive Adenylate Cyclase", "subitem_title_language": "en"}]}, "item_type_id": "3", "owner": "25", "path": ["430"], "permalink_uri": "https://kwmed.repo.nii.ac.jp/records/601", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2017-01-23"}, "publish_date": "2017-01-23", "publish_status": "0", "recid": "601", "relation": {}, "relation_version_is_last": true, "title": ["ノルアドレナリン感受性アデニル酸シクラーゼに及ぼすリチウム慢性投与の効果"], "weko_shared_id": -1}
ノルアドレナリン感受性アデニル酸シクラーゼに及ぼすリチウム慢性投与の効果
https://kwmed.repo.nii.ac.jp/records/601
https://kwmed.repo.nii.ac.jp/records/6012da87476-8ddc-4d87-950d-d3e8c486150b
名前 / ファイル | ライセンス | アクション |
---|---|---|
KJ00009816479.pdf (445.7 kB)
|
|
Item type | [ELS]学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-01-23 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | ノルアドレナリン感受性アデニル酸シクラーゼに及ぼすリチウム慢性投与の効果 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Effect of Chronic Lithium Administration on Noradrenaline-Sensitive Adenylate Cyclase | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
笹野, 友寿
× 笹野, 友寿× Sasano, Tomohisa |
|||||
著者所属(日) | ||||||
ja | ||||||
川崎医科大学精神科 | ||||||
著者所属(英) | ||||||
en | ||||||
Department of Psychiatry, Kawasaki Medical School | ||||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Noradrenaline-sensitive adenylate cyclase | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Lithium | |||||
記事種別(日) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 原著 | |||||
言語 | ja | |||||
抄録(日) | ||||||
ja | ||||||
ノルアドレナリン受容体に連関したアデニル酸シクラーゼの感受性に及ぼすリチウム慢性投与の効果を若年ラットの前頭皮質と海馬の組織スライスを用いて検討した.その結果,前頭皮質ではリチウム慢性投与によってノルアドレナリン刺激による組織スライスのcyclic AMP増加量は有意に抑制された(p<0.001).なお,血清リチウム濃度は0.54mEq/lであった.したがって,リチウムの抗うつメカニズムはノルアドレナリン感受性アデニル酸シクラーゼの感受性阻害作用と何らかの関連性があるものと推察できる. | ||||||
抄録(英) | ||||||
en | ||||||
The effect of chronic administration of lithium on noradrenaline-sensitive adenylate cyclase was examined. The serum lithium level was 0.54mEq/l. Cyclic AMP accumulation in a slice of the frontal cortex was significantly inhibited by lithium (p<0.001). It is suggested that the antidepressive mechanism of lithium is somewhat related to the effect of inhibition of the noradrenaline sensitivity of adenylate cyclase in the frontal cortex. | ||||||
書誌情報 |
ja : 川崎医学会誌 en : Kawasaki medical journal 巻 13, 号 2, p. 128-132, 発行日 1987 |
|||||
URL | ||||||
識別子 | http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1987/KMJ13(2)128-132.1987.pdf | |||||
識別子タイプ | URI | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.11482/KMJ-J13(2)128 | |||||
ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0386-5924 | |||||
ISSN | ||||||
収録物識別子タイプ | EISSN | |||||
収録物識別子 | 2758-089X | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00045593 | |||||
雑誌書誌ID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN12940574 | |||||
著者版フラグ | ||||||
出版タイプ | VoR |