| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-01-23 |
| タイトル |
|
|
タイトル |
Investigation of the Therapeutic Effect of Tobramycin in Mice with Experimental Pneumonia in One-shot Versus Divided-dose Schedules |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
SOEJIMA, Rinzo
NIKI, Yoshihito
KAWANISHI, Masayasu
MATSUSHIMA, Toshiharu
KATOH, Osamu
NAKAHAMA, Chikara
|
| 著者所属(英) |
|
|
|
en |
|
|
Division of Respratory Disease, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Respratory Disease, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Respratory Disease, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Respratory Disease, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Respratory Disease, Department of Medicine, Kawasaki Medical School |
| 著者所属(英) |
|
|
|
en |
|
|
Division of Respratory Disease, Department of Medicine, Kawasaki Medical School |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Plasma concentration of tobramycin |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Klebsiella pneumoniae pneumonia |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Formaldehyde |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
inhaledmou se |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Therapeutic effect of tobramycin |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original Article |
|
言語 |
en |
| 抄録(英) |
|
|
|
en |
|
|
We measured the plasma levels of tobramycin administered by different methods and evaluated the therapeutic effects of tobramycin in mice with experimental pneumonia in various methods and dose schedules. (1) Mice were dosed with tobramycin intramuscular, intravenous oneshot injection and drip infusion, and intramuscular injection in divided doses at intervals of 15 minutes. The plasma concentration of the drug was determined at timed intervals after administration in each instance. Intramuscular and one-shot intravenous injections resulted in substantially parallel time courses of plasma concentration and plasma concentration with drip infusion was similar to that after divided intramuscular injection. (2) A therapeutic experiment was conducted in mice with Klebsiella pneumoniae pneumonia using one-shot and divided intramuscular injection methods of tobramycin. The one-shot injection group showed a satisfactory result at the dose level of 2 mg/kg, but the injection in four divided doses yielded better results at 1 mg/kg. Therefore, in cases where high doses are not feasible or are undesirable, the time of contact of the bacteria and the drug should be prolonged, rather than trying to increase the peak plasma concentration of the drug. |
| 書誌情報 |
en : Kawasaki medical journal
巻 9,
号 2,
p. 99-107,
発行日 1983
|
| URL |
|
|
識別子 |
http://igakkai.kms-igakkai.com/wp/wp-content/uploads/1983en/9(2)99-107.1983.pdf |
|
識別子タイプ |
URI |
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.11482/KMJ-E9(2)99 |
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0385-0234 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2434-3404 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00710169 |
| 雑誌書誌ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12029005 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
KJ00010227619.pdf (705.4 kB)
